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Ying-Mei Lu Selected Research

3- (2- (4- (3- chloro- 2- methylphenyl)1- piperazinyl)ethyl)5,6- dimethoxy- 1- (4- imidazolylmethyl)- 1H- indazol dihydrochloride 3.5 hydrate

2/2010Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.
1/2009DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.
12/2007Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.

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Ying-Mei Lu Research Topics

Disease

7Ischemia
01/2019 - 02/2010
5Hypertrophy
04/2013 - 12/2007
4Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
12/2019 - 02/2012
3Autistic Disorder (Autism)
11/2022 - 01/2014
3Cognitive Dysfunction
12/2019 - 05/2013
3Inflammation (Inflammations)
01/2019 - 04/2016
3Cardiomegaly (Heart Hypertrophy)
04/2013 - 01/2009
2Epilepsy (Aura)
09/2022 - 12/2011
2Seizures (Absence Seizure)
09/2022 - 01/2020
2Embolism (Embolus)
01/2019 - 08/2011
2Autism Spectrum Disorder
10/2016 - 03/2016
2Brain Injuries (Brain Injury)
04/2016 - 06/2015
2Brain Ischemia (Cerebral Ischemia)
04/2016 - 01/2013
2Heart Failure
01/2011 - 02/2010
1Weight Loss (Weight Reduction)
11/2021
1Anorexia
11/2021
1AIDS-Related Complex (ARC)
11/2021
1Vascular Remodeling
01/2021
1Diabetic Retinopathy (Retinopathy, Diabetic)
01/2021
1Anxiety Disorders (Anxiety Disorder)
10/2019
1Atherosclerosis
01/2018
1Hypoglycemia (Reactive Hypoglycemia)
11/2017
1Memory Disorders (Memory Loss)
06/2017
1Cerebrovascular Trauma
09/2015
1Stroke (Strokes)
07/2014
1Urolithiasis
06/2014
1Experimental Diabetes Mellitus
05/2013
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2013
1Brain Diseases (Brain Disorder)
02/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
02/2012
1Alzheimer Disease (Alzheimer's Disease)
02/2012
1Ischemic Stroke
02/2012

Drug/Important Bio-Agent (IBA)

7Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
09/2022 - 12/2007
4Proteins (Proteins, Gene)FDA Link
09/2022 - 02/2010
3Peroxynitrous Acid (Peroxynitrite)IBA
11/2021 - 02/2012
3MelatoninIBA
11/2017 - 08/2011
3Calmodulin (Calcium-Dependent Activator Protein)IBA
12/2016 - 02/2010
33- (2- (4- (3- chloro- 2- methylphenyl)1- piperazinyl)ethyl)5,6- dimethoxy- 1- (4- imidazolylmethyl)- 1H- indazol dihydrochloride 3.5 hydrateIBA
02/2010 - 12/2007
2Oxygen (Dioxygen)IBA
01/2021 - 08/2011
2Pharmaceutical PreparationsIBA
12/2016 - 02/2010
2AntioxidantsIBA
04/2016 - 07/2014
2Tight Junction ProteinsIBA
01/2013 - 08/2011
2CalcineurinIBA
05/2010 - 12/2007
2Calcium-Calmodulin-Dependent Protein KinasesIBA
05/2010 - 01/2009
2DystrophinIBA
02/2010 - 12/2007
23- (2- (4- (3- chloro- 2- methylphenyl)- 1- piperazinyl)ethyl)- 5,6- dimethoxyindazoleIBA
01/2009 - 12/2007
2Endothelin-1 (Endothelin 1)IBA
01/2009 - 12/2007
1Biomarkers (Surrogate Marker)IBA
11/2022
1Biological ProductsIBA
11/2022
1RNA (Ribonucleic Acid)IBA
09/2022
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
09/2022
1Brain-Derived Neurotrophic Factor (BDNF)IBA
09/2022
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
11/2021
1Cisplatin (Platino)FDA LinkGeneric
11/2021
1Uric Acid (Urate)IBA
11/2021
1Semaphorins (Semaphorin)IBA
01/2021
1Retinaldehyde (Retinal)IBA
01/2021
1CateninsIBA
01/2021
1Ceftriaxone (Ceftriaxon)FDA LinkGeneric
01/2020
1Chemokine ReceptorsIBA
01/2020
1levamlodipine besylateIBA
12/2019
1Messenger RNA (mRNA)IBA
10/2019
1Cathepsin BIBA
01/2019
1Ribosomal Proteins (Ribosomal Protein)IBA
01/2018
1Tetracycline (Achromycin)FDA LinkGeneric
01/2018
1indoleIBA
11/2017
1MicellesIBA
12/2016
1CarbohydratesIBA
12/2016
1PolymersIBA
12/2016
1polysialic acidIBA
12/2016
1GTP-Binding Proteins (G-Protein)IBA
10/2016
1LigandsIBA
10/2016
1Protein Kinases (Protein Kinase)IBA
10/2016
1Small Interfering RNA (siRNA)IBA
04/2016
1LipopolysaccharidesIBA
04/2016
1IsoenzymesIBA
04/2016
1Heme Oxygenase-1IBA
04/2016
1Toll-Like Receptors (Toll-Like Receptor)IBA
04/2016
1Valproic Acid (Depakote)FDA LinkGeneric
03/2016
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
06/2015
1PeroxiredoxinsIBA
08/2014
1Vitamin KFDA Link
06/2014
1Vitamin K Epoxide ReductasesIBA
06/2014
1EnzymesIBA
06/2014
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2014
1Streptozocin (Streptozotocin)FDA Link
05/2013
1SA 4503IBA
04/2013
1Adenosine Triphosphate (ATP)IBA
04/2013
1OccludinIBA
01/2013
12'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA
01/2013
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2013
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2013
1Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2012
1Neuregulin-1 (Neuregulin 1)IBA
12/2011
1Anticonvulsants (Antiepileptic Drugs)IBA
12/2011
1Pilocarpine (Ocusert)FDA LinkGeneric
12/2011

Therapy/Procedure

2Microspheres (Microsphere)
01/2019 - 08/2011
2Therapeutics
12/2016 - 02/2012
1Drug Therapy (Chemotherapy)
11/2021
1Lasers (Laser)
09/2015